| Antigen: |
Fbw7 (also known as hDCD4) |
| Relevance: |
SCF ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The Fbw7/hCdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF(Fbw7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. Fbw7 thus negatively regulates several key oncoproteins. Accordingly, Fbw7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and Fbw7 functions as a haplo-insufficient tumor suppressor in mice. |
| Clone: |
FBOX 3a9/1 |
| Subclass: |
IgG1 |
| Applications: |
Western, Immunoprecipitation, Histocytochemistry, Paraffin embedded |
| Immunogen: |
Synthetic peptide |
| Reactivity: |
Human and Mouse |
| Species raised in: |
Mouse |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
E4 + 5% FCS |
| References: |
Nateri et al. 2004, Science, 303, 1374-8. |
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