CD49d (integrin alpha 4) is a 150 kDa protein characterised by a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain. Hetrodimers are formed with integrin beta 1 and 7. BU49 induces phosphorylation of a cAMP response element-binding protein (CREB) in the human monocyte-like cell line, U937.
Clone:
BU49
Subclass:
IgG1
Applications:
Immunoprecipitation, FACS
Immunogen:
Hiatt myeloma cell line
Reactivity:
Human. Not yet tested in other species
Species raised in:
Fusion partner:
Non secreting plasmacytoma NSO/BALB/c mouse spleen cell; date of fusion: May 1987
Recommended growth conditions:
RPMI 1640 + 10% FCS
References:
Ikewaki, N. and Inoko, H. 2002 Microbiol. Immunol. 46(10):685-695
Leucocyte Typing VI 1997 Garland Publishing
Nojima, Y. et al. 1992 J.Exp.Med 175:1045-53
Notes:
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