| Antigen: |
TCP-1 (T-complex polypeptide-1; CCTalpha) |
| Relevance: |
TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. |
| Clone: |
23C |
| Subclass: |
IgG2c |
| Applications: |
Western blot, Immunoprecipitation, Immunofluorescence |
| Immunogen: |
C-terminal half of the full length murine TCP protein |
| Reactivity: |
Mouse, Chicken, Hamster, Rat, Dog |
| Species raised in: |
Rat |
| Fusion partner: |
Y3 Ag 1.2.3 rat myeloma |
| Recommended growth conditions: |
DMEM + 5%FCS |
| References: |
Willison K et al. 1989. Cell. 57:621-632 
Harrison-Lavoie et al. 1993. EMBO J . 12:2847-2853
Sternlicht H et al. 1993. PNAS USA 90:9422-9426 |
| Notes: |
Epitope: 554 LDD-COOH. 23C binds protein A and is useful for native precipitation of CCT and golgi coatomer. Does not recognise primate, xenopus or yeast TCP-1 |
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