| Antigen: |
CD45 RO |
| Relevance: |
CD45 is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple CD45 isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. UCH-L1 may identify abnormalities of functional T-cell subsets in immune disorders and can be used in tumour diagnosis by FACS or immunohistology. Very useful in studies of human T cell function and ontogeny. |
| Clone: |
UCH-L1 |
| Subclass: |
IgG2a |
| Applications: |
FACS, Immunohistochemistry (Paraffin embedded, Frozen), Western blot,Immunoprecipitation |
| Immunogen: |
Cultured T cells from
an IL-2-dependent T-cell line (CA1) prepared from human
peripheral blood activated with influenza virus |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
P3/NS1/1-Ag4-1 |
| Recommended growth conditions: |
RPMI +10% FCS |
| References: |
Smith SH et al. 1986. Immunol. 58:63-70 
Dornan S et al. 2002. J. Biol. Chem. 277(3):1912-8 |
| Notes: |
- |
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Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
