| Antigen: |
Epidermal Growth Factor Receptor (EGFR); Her1. Recognises external domain. |
| Relevance: |
The EGFR family of type
I growth factor receptor tyrosine kinases includes EGFR
(HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4
(HER4). EGFR is overexpressed in many
common solid human squamous cell carcinomas. A cell
surface molecule (175kDa MW) which can be specifically
cross-linked to EGF, exhibits an EGF-stimulated protein
kinase activity and is coded for by a gene on human
chromosome 7. |
| Clone: |
EGFR1 |
| Subclass: |
IgG2b |
| Applications: |
Immunoprecipitation, Immunohistochemistry(Frozen) |
| Immunogen: |
Human epidermoid carcinoma line A431 |
| Reactivity: |
- |
| Species raised in: |
Mouse: Male Balb/c |
| Fusion partner: |
P3-NS1/1-Ag4-1 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Waterfield MD et al. 1982.
J. Cell. Biochem. 20:149-161 
Gullick WJ et al. 1986. Cancer Res. 46:285-292 |
| Notes: |
(175 kDa MW) |
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