| Antigen: |
ERCC1 |
| Relevance: |
Nucleotide excision
repair (NER) is a DNA
repair pathway that removes lesions induced by a variety
of agents such as UV irradiation. ERCC1 binds to XPF
to form the heterodimer ERCC1-XPF, which is a DNA endonuclease
that is essential for the dual incision step of NER
(cleaves 5' of the DNA lesion). Some publications report
that ERCC1 is elevated in cisplatin-resistant cells. |
| Clone: |
3H11 |
| Subclass: |
IgG2a |
| Applications: |
Western blot |
| Immunogen: |
Full length HIS-tagged recombinant ERCC1 |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Biggerstaff M et al. 1993. EMBO J. 12(9):3685-92.  |
| Notes: |
Positive control: A431 cells or HeLa. 33-36 kDa MW |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
