| Antigen: |
HLA-DR β 1st domain and DP. |
| Relevance: |
Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 14.1 can be used for tissue typing and characterisation of human HLA class II molecules. |
| Clone: |
TAL 14.1 |
| Subclass: |
IgG2a |
| Applications: |
ELISA, FACS, Western blot, Immunohistochemistry(Paraffin embedded) |
| Immunogen: |
P815 transfectant expressing a human/mouse hybrid molecule: human HLADR4b1 domain in a mouse IE background. |
| Reactivity: |
Human |
| Species raised in: |
- |
| Fusion partner: |
NS1 |
| Recommended growth conditions: |
RPMI 1640 + 10% FCS. |
| References: |
Maddox J & Bodmer J. 1989. Immunobiology of HLA II:373-375. Springer-Verlag New York (NB called X1.26 in this paper) |
| Notes: |
Cytotoxic with rabbit complement. Western blots to dimer + DR beta chain. |
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