| Antigen: |
Integrin αX
(CD11c; gp150/95 α subunit) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of α and β
subunits, which mediate cell-cell and cell-extracellular
matrix attachments. Aberrant integrin expression has
been found in many epithelial tumours. Changes in integrin
expression have been shown to be important for the growth
and early metastatic capacity of melanoma cells. Integrin
αX is found on hairy cell leukaemias
and malignant histiocytes and on tissue macrophages,
monocytes, activated neutrophils and some T-cell clones. |
| Clone: |
3.9 |
| Subclass: |
IgG1 |
| Applications: |
Immunoprecipitation, FACS Immunohistochemistry (Frozen) |
| Immunogen: |
Rheumatoid synovial fluid cells and fibronectin purified human monocytes |
| Reactivity: |
- |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/o-Ag14 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Hogg
N et al. 1986. Eur. J. Immunol. 16:240 -248. 
Leucocyte
Typing III. Edited by McMichael AJ et al. 1997 |
| Notes: |
Recognises the 150Kd alpha subunit CD11c (of CD11c/CD18 or p150,95) Positive control: monocytes or neutrophils |
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