| Antigen: |
Integrin β1 (CD29) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of α and β
subunits, which mediate cell-cell and cell-extracellular
matrix attachments. Aberrant integrin expression has
been found in many epithelial tumours. Changes in integrin
expression have been shown to be important for the growth
and early metastatic capacity of melanoma cells. Loss
of integrin β1 is associated with the development
of some epithelial tumours. |
| Clone: |
4B7 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (Paraffin embedded), Immunoprecipitation, FACS, Immunofluorescence |
| Immunogen: |
Ocular melanoma cell line V+B2 |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c. |
| Fusion partner: |
|
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Marshall JF et al. 1998. Br. J. Cancer. 77(4):522-529  |
| Notes: |
- |
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