| Antigen: |
p53; human, large T-associated form |
| Relevance: |
p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. Pab 1103 is useful as research reagent to investigate structural similarity between large T and p53. |
| Clone: |
PAb 1103 |
| Subclass: |
IgM |
| Applications: |
Immunoprecipitation |
| Immunogen: |
A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis. |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
- |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Leppard K & Crawford L. 1983. EMBO J. 2:1457-1464. 
Leppard K & Crawford L. 1984. J. Virol. 50:457-464. |
| Notes: |
Positive control: MDA-MB-231
cell line |
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