| Antigen: |
p53; cross reacts with human p53 and an oligomeric form of SV40 large T-antigen. |
| Relevance: |
p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb 1104. |
| Clone: |
PAb 1104 |
| Subclass: |
IgM |
| Applications: |
Immunoprecipitation |
| Immunogen: |
A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis. |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
NS-1 |
| Recommended growth conditions: |
RPMI 1640 + 5% FCS |
| References: |
Leppard K and Crawford L. 1983. EMBO J. 2:1457-1464. 
Leppard K and Crawford L. 1984. J. Virol. 50:457-464. |
| Notes: |
Positive control: MDA-MB-231
cell line |
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