| Antigen: |
Placental alkaline phosphatase (PLAP) |
| Relevance: |
Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. HD 8B6 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes. |
| Clone: |
HD 8B6 |
| Subclass: |
IgG2a |
| Applications: |
Immunohistochemistry (Frozen, Paraffin embedded), ELISA, Radioimmunoassay |
| Immunogen: |
Fresh Hep-2 cells followed by booster injections of fresh Hep-2 cells that had had their surface expression of PLAP boosted in culture. |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
P3/NS1/1-Ag4-1 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Durbin H et al. 1988.
Int. J. Cancer Supplement. 2:50-58 
Durbin H et al. 1988. Int. J. Cancer Supplement. 2:59-66 |
| Notes: |
- |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
