| Antigen: |
XRCC3 |
| Relevance: |
XRCC3 (X-Ray Repair
Cross Complementing 3) is a RAD51 paralog. RAD51
is a eukaryotic homologue of E. coli RecA, a recombinase,
and a component of the homologous recombination DNA
repair pathway. RAD51 forms a nucleoprotein filament
(through binding RAD52 and single stranded DNA that
are exposed following double strand breaks) that initiates
recombination. XRCC3 is also components of the
homologous recombination pathway. |
| Clone: |
XRCC3 10F1/6 |
| Subclass: |
IgG1 |
| Applications: |
Western blot |
| Immunogen: |
Raised against his-tagged human XRCC3, overexpressed in e.coli and purified on a talon affinity column under denaturing conditions, followed by gel purification on a SDS-Page |
| Reactivity: |
- |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/0 Ag.14 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Masson J-Y et al. 2001.
Genes Dev. 15:3296-3307 
Masson J-Y et al. 2001. Proc. Natl. Acad. Sci. USA.
98:8440-8446
Tebbs RS et al. 1995. Proc. Natl. Acad. Sci. USA. 92:6354-6358 |
| Notes: |
Does not recognise XRCC3
in HeLa total extracts- suggest nuclear extracts. 37.8
kDa MW |
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