Iduronate Scalable Chemistry Methods
Description
A novel, scalable synthetic route has been developed and optimised for the production of synthetic polysaccharides containing the L-iduronate subunit e.g. heparin-type polysaccharides. Reactions at ambient temperature using inexpensive reagents and the key stereochemical step involving purification by crystallization enables large-scale synthesis, facilitating access to larger amounts of various L-iduronate targets. Scalability underpins the potential for viable development of L-ido-containing heparan-related saccharides for clinical evaluations. The patent portfolio is available for licensing in the fields of research tools and therapeutic development outside of CRT’s Oligosaccharides as Inhibitors of Angiogenesis programme.
For more information please contact
Dr Martyn Bottomley
+44 (0) 20 3469 6300 .(JavaScript must be enabled to view this email address)