Integrin avß6 Binding Peptide for Imaging and Tumour Targeting
Validation
A series of proprietary short peptides have been developed that show remarkable binding affinity and selectivity for the integrin ανβ6, which is over-expressed in a range of tumours including more than 90% of oral squamous cell pancreatic and ovarian carcinomas and 40% of lung, colon and breast tumours. ανβ6 plays an active role in tumour progression, with high expression being linked to poor prognosis in some tumour types. Preclinical in vivo studies demonstrate the utility of the peptides as either imaging or tumour targeting agents for ανβ6-expressing tumours. A patent portfolio and unpublished data are available for exclusive licensing.
Contact: Enquiries enquiries@CancerTechnology.com
 Further details can be accessed here
RKIP: A Marker of Colorectal Cancer Metastatic Potential
Validation
There is an urgent need to develop prognostic markers that can identify the 30-60% of Dukes B and C colorectal cancer patients that suffer tumour recurrence. Raf-1 kinase inhibitor protein (RKIP) has been identified as an independent marker of increased risk of tumour relapse. Survival data demonstrate that level of RKIP expression in primary CRC’s is significantly and inversely associated with metastatic disease. Patent application, data and proprietary antibodies are available for collaborative development or licensing.
Contact: Dr Phil Masterson, pmasterson@CancerTechnology.com
Further details can be accessed here
MCM Proteins – Early Stage Diagnostic Cancer Biomarkers
Validation
MCM or minichromosome maintenance family proteins are essential for the initiation of DNA replication. Data is now available to demonstrate that antibodies against MCMs enable the ready identification of malignant and pre-malignant cells in a variety of samples, including cervical smears, anal smears, oral smears, sputum (for lung cancer), urine and stool samples. Diagnostic products based on antibodies targeting MCM proteins are currently being developed for cervical and bladder cancer with commercial partners. CRT are now looking for a commercial partner to develop MCM based diagnostic tests for other cancer indications. Granted patents (US, EP and JP) relating to the target antigen are available for licensing
Contact: Dr Adrian Ibrahim, aibrahim@CancerTechnology.com
Further details can be accessed here for Anal Cancer
Further details can be accessed here for Colorectal Cancer
Further details can be accessed here for Lung Cancer
Further details can be accessed here for Oral Cancer
Single Nucleotide Polymorphisms that Predict Colorectal Cancer Risk
Discovery
The SNPs were discovered through Cancer Research UK funded genome wide association scans (GWAS) designed to identify low penetrance genetic changes that may be indicative of an increased risk of colorectal cancer. This led to recent publications describing the identification of the first common genetic variants for CRC predisposition including at the HMPS/CRAC locus on 15q13 and the SMAD7 gene on 18q21. CRT holds a patent portfoliio protecting a number of SNPs that predict increased colorectal cancer risk. The portfolio is available for non-exclusive licensing. Development of risk-profiling tests based on these SNPs, and their application in improved population screening programmes may result in better screening for cancer in those most at risk.
Contact: Dr Laura Fletcher, lfletcher@CancerTechnology.com
Further details can be accessed here
Lamin A/C: A Prognostic Marker for Early Colorectal Cancer
Discovery
There is an urgent need to develop prognostic markers that can identify the 30-60% of Dukes B & C colorectal cancer patients that suffer tumour recurrence. Expression of the nuclear lamins A/C has been identified as an independent marker of increased risk of tumour relapse. Cox hazard ratio scoring of immunohistochemical data from >650 independent CRC tumour samples scoring indicates that patients expressing lamin A/C are twice as likely to suffer CRC-related death compared to patients lacking the biomarker. A patent, proprietary monoclonal antibodies and data, are available for licensing.
Contact: Dr Laura Fletcher, lfletcher@CancerTechnology.com
Further details can be accessed here
Prostate Cancer Susceptibility Loci and SNPs
Discovery
Although there is a clear familial risk associated with prostate cancer only a few susceptibility genes have been identified so far. Genome Wide Association Studies (GWAS) have now been used in many diseases to identify disease related loci and when sufficiently powered such studies can also identify low penetrance disease associated genes and single nucleotide polymorphisms (SNPs). Diagnostics based on panels of such genes/polymorphisms may be able to identify high risk individuals for whom increased clinical monitoring may be justified. This technology is based on the identification of seven independently significant SNPs found to be associated with prostate cancer and a number of them are linked to genes that may play functional roles in prostate cancer. The seven SNPs are the subject of a recently filed patent application and are likely to be of value in evaluating prostate cancer risk.
Contact: Dr Angus Lauder, alauder@CancerTechnology.com
Further details can be accessed here
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