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Relevance: In vitro study and comparison of genetic instability in myeloma tumour lines (homoplastic with JIM3); in vitro study of effects of DNA repair deficiency in myeloma tumour lines.
Relevance: In vitro study and comparison of genetic instability in myeloma tumour lines (homoplastic with JIM1); in vitro study of effects of DNA repair deficiency in myeloma tumour lines.
Relevance: The prospective commercial application of the line is in the generation of in vitro epidermal ‘skin equivalents’ to be used as screening tools to look at the activity of NCE’s and/or NBE’s of dermatological interest, and/or to screen for such NCE and/or NBE in high throughput systems. It may also be of use to non-pharmaceutical healthcare and/or cosmetic companies involved in the personal vitality and/or beauty product development segments.
Relevance: In vitro study of ERBB2 proto-oncogene over-expression in human mammary epithelia; in vitro study of the effects of ERBB2 over-expression on epithelial morphology & adhesion. The MTSV1-7 ce1 cell line is an ideal tool for investigation of the role of the ERBB2 receptor proto-oncogene in breast cancer morphogenesis and adhesion. MTSV1-7 ce1 cells over-express the ERBB2 receptor, inducing a reduced ability to undergo morphogenesis in vitro, and reduced expression of surface adhesion molecules E-Cadherin and a2 integrin. Inhibition of morphogenesis and transcription of adhesion molecules in human mammary epithelial cells can be affected by signals generated by the ERBB2 receptor, suggesting a role for ERBB2 over-expression in tumour progression and metastasis.
Relevance: Helper-free packaging cell line & shuttle vector system enabling high-titer production of recombinant retroviral vectors for mammalian gene transfer, with significantly reduced probability of replication-competent retrovirus generation.
Relevance: In vitro study of p300 knockout in colon carcinoma cell line; in vitro study of the role of p300 in p53-dependent apoptosis, cellular adhesion and migration.
Relevance: Maybe useful for the study of the progression of carcinogenesis and for use as a model of the clinical scenario where residual cancer persists after surgery.
Relevance: In vitro model of mechanism of oestragen action on ovarian adenocarcinoma, and oestragen responsiveness at different stages of disease; in vitro investigation of efficacy/toxicity of oestragen antagonists.
Relevance: This cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists.
Relevance: Useful for studying the role of PKCe in various biological processes.
Relevance: Clonal MEFs derived from PKCepsilon knockout embryos with PKCe re-expressed. Stably transfected with pcDNA3 CMV/IE hygo+ PKCe. Matched isogenic cell line which is null for PKCe is also available. Useful for studying the role of PKCe in various biological processes.
Relevance: Knockin of oncogenic Raf-1FF/FF; in vivo study of oncogenic Raf-1 mutant and Ras signalling.
Relevance: A human buccal tumour cell line isolated from neck metastasis. Cells form undifferentiated, non-keratinised stratified epithelium sharing many morphological and functional characteristics of normal mucosa. The TR146 cell line represents a potentially unique in vitro model of buccal mucosa. The cell line has been well characterised and is an ideal tool for permeability and absorption studies. Due to morphological similarities and comparable permeability, excised porcine buccal mucosa has been considered a reasonably good model of human buccal mucosa for drug delivery studies. However, for rapid and efficient screening of drug permeability, a cell line generally holds advantages over in vitro models of excised tissue. TR146 therefore represents a good and potentially unique model of human mucosa.
Relevance: Novel interconnections between DNA replication, DNA damage checkpoint signalling and antiviral-like autoimmune responses.
Relevance: This cell line can be used to study ULK1-dependent processes, including autophagy. A more complete phenotype requires depletion of ULK2 by RNAi .
Relevance: This cell line can be used as a wild-type control with ULK1 KO MEF (IM) to study ULK1-dependent processes, including autophagy.
Relevance: In vivo study of UNG knockout and DNA mismatch mutation during DNA synthesis.
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