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Relevance: In vivo study of JAM-C knockout; in vivo study of spermiogenesis; in vivo study of neuronal networks and integrity.
Relevance: In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation
Relevance: In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma).
Relevance: In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)
Relevance: Skin tumourigenesis model (chemically induced); in vivo study of FGFR2 IIIb isoform knockout in skin. The mouse lives a normal life span but has altered hair morphology. It has a tendency to develop skin papillomas spontaneously and development of these can be accelerated greatly by use of a carcinogen.
Relevance: In vivo study of LFA-1 knockout; in vivo study of inflammation and leukocyte recruitment.
Relevance: Conditional knockin of oncogenic B-Raf V600E; in vivo study of oncogenic B-Raf mutation and signalling pathways
Relevance: Mimics the expression of D594ABRAF in human cancer samples. In conjunction with oncogenic G12DKRAS, this mutant induces the development of highly aggressive malignant melanomas.
Relevance: Homozygous -/- mutant mice indistinguishable from their +/- heterozygous and +/+ wild-type siblings
Relevance: In vivo study of p23 knockout, golgi apparatus and early secretory pathway function.
Relevance: Cre expressed under Pdgfrb promoter enabling conditional recombinase expression in pericytes and smooth vascular muscle cells (tissue-specific loxP knockout/knockin/transgene).
Relevance: In vivo study of p110alpha disruption and Ras signalling.
Relevance: Investigating the biological role of PKCepsilon (e.g. required for macrophage activation and defence against bacterial infection, roles in cell division).
Relevance: Transgenic mouse expressing tamoxifen-inducible creERT2 under the control of Prox1 gene promoter Allows specific and temporally controlled cre-loxP recombination (gene inactivation/activation) in Prox1-expressing tissues, including lymphatic endothelia. Efficient recombination is observed during all developmental stages (embryonic, postnatal) and in adults. Currently no other models are available that allow such efficient and specific targetting of lymphatic vasculature.
Relevance: In vivo study of Raf-1 knockout and Ras signalling
Relevance: Knockin of oncogenic Raf-1D486A; in vivo study of oncogenic Raf-1 mutant and Ras signalling.
Relevance: Knockin of inactive Raf-1FF/FF mutant; in vivo study of inactive Raf-1 mutant and Ras signalling.
Relevance: The knock-out mouse was developed to demonstrate a significant role for RalGDS in Ras-dependent carcinogenesis in vivo. Lack of RalGDS resulted in reduced tumour incidence, size and progression to malignancy in multistage skin carcinogenesis, and reduced transformation by Ras in tissue culture. Experiments performed in cells isolated from skin tumours suggested that RalGDS mediates cell survival through the activation of the JNK/SAPK pathway.
Relevance: RIP140 is a ligand-dependent corepressor for most nuclear receptors, and functions through interaction with their AF2 activation domains.Scientific objective was to elucidate the function of RIP140 is oestrogen receptor signalling but was subsequently extended to include other nuclear receptors. This mouse maybe useful for studying compounds targeting RIP140 in fertility and obesity associated disorders.
Relevance: In vivo study of SAP-1 knockout; in vivo study of positive T cell selection & development.
© Cancer Research Technology 2012