| Antigen: | Activating Protein 2 (AP-2) beta |
| Clone: | AP2bß 1F3/8 |
| Subclass | IgG2a |
| Species Raised In: | Balb/c |
| Immunogen: | Truncated AP-2ß protein prepared from bacteria |
| Positive Control: | Human breast cancer line MDA MB 453 |
| Cross Reactivity: | Human |
| Applications: | ELISA, Paraffin embedded, Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2/0Ag.14 |
| Synonyms: | Transcription factor AP-2-beta, Activating enhancer-binding protein 2-beta, TFAP2B |
| Relevance: | AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2ß may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. |
| References: | Personal communication. |
| Notes: | Antigen recovery using microwave or pressure cooking required for paraffin embedded tissue. |
© Cancer Research Technology 2012