Anti AP-2 (a & ß) Clone A6/2/2 Profile

Antigen: Activating Protein 2 (AP-2) alpha and beta forms
Clone: A6/2/2
Subclass IgG1
Species Raised In:

Mouse

Immunogen: Peptide to C-Terminal of AP-2 Alpha coupled to KLH. PNSHTDNNAKSSDKEEKHRK
Epitope:

Potentially the last 8 residues as these are common between alpha and beta forms.

Positive Control:

Raji cells or breast carcinomas.

Cross Reactivity:

Human

Applications: ELISA, FACS, Paraffin embedded, Western
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: NSO
Relevance: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2ß may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
References:

Batsche E et al. 1998. Mol. Cell. Biol. 18(7):3647-58. PMID: 9632747 Read more
Gee JMW et al. 1999. J. Pathol. 189:514-20. PMID: 10629551 Read more

Notes:

Recommended for immunohistology using formal saline fixative with calcium on paraffin embedded specimens (10min microwave treatment required).