| Antigen: | Activating Protein 2 (AP-2) alpha (Human) |
| Clone: | AP2a 8G8/5 |
| Subclass | IgG1 |
| Species Raised In: | Balb/c |
| Immunogen: | Bacterialy expressed AP-2a/AP-2g fusion protein. |
| Positive Control: | Extract from breast cancer cell line ZR75-1 |
| Cross Reactivity: | Human |
| Applications: | Paraffin embedded, Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2/0Ag.14 |
| Synonyms: | Transcription factor AP-2-alpha, TFAP2A, AP2TF, TFAP2 |
| Relevance: | AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2ß may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. |
| References: | Personal communication |
| Notes: | AP2a 8G8/5 is specific for the alpha form of AP-2. Antigen recovery using microwave or pressure cooking required for paraffin embedded tissue. |
© Cancer Research Technology 2012