| Antigen: | Ataxia Telangiesctasia Mutated (ATM) |
| Clone: | ATM 11G12 |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | Residues 992-1144 of ATM fusion protein |
| Cross Reactivity: | Human |
| Applications: | Immunofluorescence, Immunoprecipitation, Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2/0Ag.14 |
| Relevance: | The ATM protein is a member of the phosphatidylinositol-3 kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. It is thought that the activation of ATM by autophosphorylation might be the initiating event of cellular responses to irradiation. The classic form of ataxia telangiectasia, an autosomal recessive cerebellar ataxia, results from the presence of two truncating ATM mutations, leading to a total loss of the ATM protein. |
| References: | Starczynski J et al. 2003. Am J Pathol. 163:423-32. PMID: 12875964 Read more |
| Notes: | Suggested Dilution: 1:500 |
© Cancer Research Technology 2012