| Antigen: | Aprataxin |
| Clone: | Aprataxin |
| Species Raised In: | Rabbit |
| Immunogen: | Recombinant aprataxin |
| Epitope: | Residues 1-177 |
| Positive Control: | Any normal lymphoblastoid or fibroblastoid cells/cell lines |
| Cross Reactivity: | Human |
| Applications: | Immunofluorescence, Immunoprecipitation, Western |
| Synonyms: | Forkhead-associated domain histidine triad-like protein, FHA-HIT, APTX, AXA1 |
| Relevance: | Aprataxin, a nuclear protein, is thought to be involved in single strand DNA break-repair in the cellular response to genotoxic stress through its capacity to interact with a number of proteins involved in DNA repair. These include XRCC1, XRCC4, PARP-1 and p53. The neurological disorder ataxia-oculomotor apraxia (AOA1) is caused by mutations in the APTX gene which destabilize the resultant protein, aprataxin. |
| References: | Clements PM et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105 Read more |
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