| Antigen: | Bcl-2 associated transcription factor 1 (BCLAF1, Btf) |
| Clone: | BCLAF1 |
| Species Raised In: | Rabbit |
| Immunogen: | Recombinant His-tagged protein fragment of Human BCLAF1 |
| Epitope: | Residues 287-450 of Human BCLAF1 |
| Cross Reactivity: | Human |
| Applications: | Immunoprecipitation, Western |
| Relevance: | BCL2-associated transcription factor 1 (BCLAF1), also known as BTF, is a 920 amino acid protein that localizes to both the nucleus and the cytoplasm. Overexpression of BCLAF1 promotes apoptosis by preventing the transcription of Bcl-2. Bcl-2 is one of many key regulators of apoptosis which are essential for development, tissue homeostasis and protection against foreign pathogens. Four isoforms of BCLAF1 exist due to alternative splicing events. |
| References: | Bracken CP et al. 2008. Cancer Res. 68(18):7621-8. PMID: 18794151 Read more |
| Notes: | Suggested Dilution for western blot: 1:3000 |
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