Anti BCR-ABL Clone 4C12 Profile

Antigen: BCR-ABL
Clone: 4C12
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: BCR-ABL peptide
Cross Reactivity:

Human

Applications:
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: P3X63Ag8.653
Relevance: The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.
References:

Dhut S et al. 1988. Oncogene 3(5):561-6. PMID: 3078961Read more
Dhut S. et al. 1990. Leukemia 4(11):745-50. PMID: 2232885Read more
Walker LC et al. 1987. Nature 329(6142):851-3. PMID: 3478595Read more