Anti CD4 V1 domain Clone QS4120 Profile

Antigen: CD4 V1 domain
Clone: QS4120
Subclass IgG1
Species Raised In:

Mouse

Immunogen: CD4+ transfectant followed by CEM cells
Cross Reactivity:

Human

Applications: ELISA, FACS
Growth Conditions:

DMEM + 5% FCS

Relevance: CD4 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class II molecules. CD4 cell counts are used as indicator of AIDS progression. In addition to virus binding, CD4 may have an active role in membrane fusion.
References:

Healey D et al. 1990. J. Exp. Med. 172(4):1233-42. PMID: 1698911 Read more
Dornan S et al. 2002. J. Biol. Chem. 277(3):1912-8. PMID: 11694532 Read more
Takase T et al. 1987. Br J Haematol. 66(4):497-502.PMID: 3117089 Read more
Notes:

QS4120 inhibits HIV sycytium function in cocultivation assays.