Anti CYP4A1 & CYP2C11 Clone Clo1 Profile

Antigen: Cytochromes P450 CYP4A1 & CYP2C11
Clone: Clo1
Subclass IgG2b
Species Raised In:

Mouse

Immunogen: Rat liver cytochrome P450 2C11 and 4A1
Cross Reactivity:

Rat

Applications: ELISA, Western
Growth Conditions:

DMEM + 5% FCS

Relevance: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
References:

"Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 205 at the VIIIth Inter. Symp. on Microsomes and Drug Oxidations, Stockholm, Sweden, June 25-26, 1990.
Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family, Abstract 1.36 at the 12th Eur. Work. on Drug Metabolism, Basel, Switzerland, Sept. 16-21, 1990.