Anti Cx43 Clone Connexin43 Profile

Antigen: Connexin 43 (Cx43 or alpha-1)
Clone: Connexin43
Subclass IgG
Species Raised In:

Mouse

Immunogen: Connexin 43 C-terminal peptide residues: 131-142. EIKKFKYGIEEH-C 131-142
Epitope:

Residues 136-142 of alpha1 connexin (KYGIEEH)

Positive Control:

Heart & liver tissue from 6 week old mice; Heart tissue expresses predominantly Cx43

Cross Reactivity:

Mouse

Applications: Acetone, Frozen, Immunofluorescence, Western
Growth Conditions:

RPMI 1640 + 10-20% FBS + glutamine (2mM)

Fusion Partner: P3X63Ag8.653
Synonyms: Gap junction protein alpha 1 antibody, GJA1 antibody
Relevance: Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.
References:

Wright CS. et al. 2001. Reproduction. 121(1):77-88. PMID: 11226030 Read more
Saitongdee P. et al. 2004. J. Histochem Cytochem 52(5), 603-15. PMID: 15100238 Read more
Pearson RA. et al. 2005. J. Neurosci 25 (46), 10803-14. PMID: 16291954 Read more
Shankar G et al.  1993. J Cell Sci. 105; 61-68. PMID: 7689577 Read more
Pearson RA. et al. 2005. J. Neurosci 25 (46), 10803-14. PMID: 16291954 Read more
Gorbe A. et al. 2007. Exp. Cell Res. 313(6): 1135-48. PMID: 17331498 Read more