Anti Cyclin A Clone E67.1 Profile

Antigen: Cyclin A
Clone: E67.1
Subclass IgG2a
Species Raised In:

Mouse

Immunogen: Bovine Cyclin A
Cross Reactivity:

Human, Murine, Bovine, Mink

Applications: Immunoprecipitation, Western
Growth Conditions:

DMEM + 5% FCS

Synonyms: CCN1 antibody, CCNA antibody
Relevance: Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. Few other monoclonal antibodies other than E67.1 are able to immunoprecipitate active CDK/Cyclin A H1 kinase from such a wide range of species.
References:

Minemoto Y et al. 2001. Exp.Cell.Res. 262(1):37-48. PMID: 11120603 Read more
Sandhu C et al. 2000. Oncogene. 19(47):5314-23. PMID: 11103932 Read more
Slingerland JM et al. 1994. Mol. Cell. Biol. 14(6):3683-94. PMID: 8196612 Read more
Matthews et al. Developmental Dynamics. 2008. 237: 124-31. PMID: 18095340 Read more