Anti EGFR Clone EGFR1 Profile

Antigen: Epidermal Growth Factor Receptor (EGFR, Her1)
Clone: EGFR1
Subclass IgG2b
Species Raised In:

Balb/c

Immunogen: Human epidermoid carcinoma line A431
Epitope:

External domain

Applications: Frozen, Immunoprecipitation
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: P3/ NS1/1-Ag4-1
Synonyms: Avian erythroblastic leukemia viral (verbb), oncogene homolog antibody
Relevance: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). EGFR is overexpressed in many common solid human squamous cell carcinomas. A cell surface molecule (175kDa MW) which can be specifically cross-linked to EGF, exhibits an EGF-stimulated protein kinase activity and is coded for by a gene on human chromosome 7.
References:

Gullick WJ et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607 Read more
Waterfield MD et al. 1982. J. Cell. Biochem. 20(2):149-61. PMID: 6188757 Read more