Anti EGFR Clone F4 Profile

Antigen: Epidermal Growth Factor Receptor (EGFR, Her1)
Clone: F4
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: Synthetic peptide (residues 985 to 996 of human EGFR) coupled to keyhole limpet hemocyanin.
Epitope:

Residues 985-996 in the Intracellular domain of human EGFR.

Applications: Acetone, ELISA, Frozen, Immunoprecipitation, Paraffin embedded
Growth Conditions:

RPMI 1640 + 5% FCS

Fusion Partner: NS1
Synonyms: Avian erythroblastic leukemia viral (verbb), oncogene homolog antibody
Relevance: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). EGFR is overexpressed in many common solid human squamous cell carcinomas.
References:

Gullick WJ et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607 Read more
Berger MS et al. 1987. J. Pathol. 152(4):297- 307. PMID: 3668732 Read more