Anti ERCC1 Clone ERCC1 3H11 Profile
| Antigen: | ERCC1 |
| Clone: | ERCC1 3H11 |
| Subclass | IgG2a |
| Species Raised In: | Balb/c |
| Immunogen: | Full length HIS-tagged recombinant human ERCC1 |
| Positive Control: | A431 cells or HeLa |
| Cross Reactivity: | Human |
| Applications: | Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2 |
| Relevance: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells. |
| References: | Biggerstaff M et al. 1993. EMBO J. 12(9):3685-92. PMID: 8253090 Read more |
