| Antigen: | ErbB3 (Her3) |
| Clone: | RTJ1 |
| Subclass | IgM |
| Species Raised In: | Mouse |
| Immunogen: | Synthetic Peptide from C terminus of human c-erbB3 |
| Epitope: | Intracellular domain |
| Cross Reactivity: | Human |
| Applications: | Immunoprecipitation, Paraffin embedded, Western |
| Growth Conditions: | RPMI 1640 + 10% FCS |
| Fusion Partner: | NSO |
| Synonyms: | Glial growth factor receptor, Receptor tyrosine protein kinase erbB 3 antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody |
| Relevance: | The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer. |
| References: | Rajkumar T et al. 1993. J. Pathol. 170(3):271-8. PMID: 8133400Read more |
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