Anti ErbB3 Clone SGP1 Profile

Antigen: ErbB3 (Her3)
Clone: SGP1
Subclass IgG1 k
Species Raised In:

Balb/c

Immunogen: c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography
Epitope:

Extracellular domain

Cross Reactivity:

Human

Applications: FACS, Immunoprecipitation
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: NSO
Synonyms: Glial growth factor receptor, Receptor tyrosine protein kinase erbB 3 antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
Relevance: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
References:

Rajkumar T et al. 1994. Br. J. Cancer. 70(3):459-65. PMID: 8080731Read more
Rajkumar T et al. 1995. The Breast. 4: 84-91.  doi:10.1016/0960-9776(95)90001-2
Srinivasan R et al. 1998. J. Pathol. 185(3):236-45. PMID: 9771476Read more