| Antigen: | F-box/WD repeat-containing protein 7 (FBW7, Cdc4) |
| Clone: | FBOX 3a9/1 |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | Synthetic peptide of human sequence |
| Cross Reactivity: | Mouse and Human |
| Applications: | Immunoprecipitation, Paraffin embedded, Western |
| Growth Conditions: | E4 + 5% FCS |
| Fusion Partner: | Sp2 |
| Synonyms: | FBX30, SEL10, FBXW7, hCdc4 |
| Relevance: | SCF (Skp, Cullin, F-box containing complex) ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 thus negatively regulates several key oncoproteins. Accordingly, FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice. |
| References: | Nateri AS et al. 2004, Science, 303(5662):1374-8. PMID: 14739463 Read more |
© Cancer Research Technology 2012