| Antigen: | Human Papilloma Virus 16 early proteins 1 and 4 (HPV-16 E1/E4). |
| Clone: | TVG402 |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | Antigen for hybridoma production was expressed as a b galactosidase fusion protein using the pEX expression system and was conse |
| Epitope: | Residues 34-39 of human papilloma virus type 16. |
| Applications: | ELISA, Frozen, Paraffin embedded, Western |
| Growth Conditions: | RPMI 1640 + 15% FCS |
| Fusion Partner: | NSO |
| Relevance: | The human papilloma virus (HPV) family of DNA tumour viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication. The monoclonal antibodies TVG 401,TVG 402 and TVG 403 represent the first against HPV16 E1/E4 and should complement those already available to E7 and L1 for the screening of frozen sections of clinical biopsies and will be of value in monitoring the progress of HPV infection from benign lesions to invasive cancer. |
| References: | Doorbar J. et al. 1992. Virology 187(1): p353-9. PMID: 1371027Read more |
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