Anti ICAM-1 Clone 15.2 Profile

Antigen: ICAM-1 (CD54)
Clone: 15.2
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: Rheumatoid synovial cells and human monocytes.
Positive Control:

Tonsil

Cross Reactivity:

Human

Applications: FACS, Immunoprecipitation, Neutralising
Growth Conditions:

E4 + 10% FCS

Fusion Partner: Sp2/0Ag.14
Relevance: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18).
References:

Dransfield I et al. 1992. J. Cell. Biol. 116:1527-35. PMID: 1541641 Read more
Stanley P et al. 2000. Biochem J. 351:79-86. PMID: 10998349 Read more