| Antigen: | K15 (a putative transmembrane protein similar to LMP2A) |
| Clone: | IF3/A10 |
| Subclass | IgG1 |
| Species Raised In: | Balb/c |
| Immunogen: | Recombinant protein |
| Epitope: | aa 345-489 |
| Cross Reactivity: | Human |
| Applications: | ELISA, Frozen, Immunohistochemistry, Western |
| Fusion Partner: | X63-Ag-8.653 |
| Relevance: | Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities. |
| References: | Sharp et al. 2002. J Virol. 76:802-16. Read more |
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