| Antigen: | Interleukin-12 (IL12) p40 subunit |
| Clone: | 1-1D5 |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | Recombinant human IL-12 produced by baculovirus. |
| Cross Reactivity: | Human |
| Applications: | ELISA, Neutralising, Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2 |
| Relevance: | IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL-12 plays a central role in cell-mediated immunity, promoting the differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL-12 is a potent stimulator of Natural Killer cells. IL-12 therapy has been suggested as a method of enhancing cytocidal anti-tumour immune responses. |
| References: | Carter RW et al. 1997. Hybridoma. 16(4):363-9. PMID: 9309427 Read more |
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