| Antigen: | Integrin a2 (CD49b) |
| Clone: | HAS-3 |
| Subclass | IgG2a |
| Species Raised In: | Mouse |
| Immunogen: | Whole human keratinocytes. |
| Cross Reactivity: | Human |
| Applications: | FACS, Frozen, Immunoprecipitation |
| Growth Conditions: | DMEM + 10% FCS |
| Fusion Partner: | Sp2 |
| Relevance: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin ß1 (CD29) to form the heterodimer integrin a2ß1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-3 co-precipitates integrin a2ß1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen. |
| References: | Alford D et al. 1998. J. Cell Sci. 111:521-32. PMID: 9443900 Read more |
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