Anti Integrin aV/ß3 Clone 23C6 Profile

Antigen: Integrin alpha V ß3 (CD51/61; Osteoclast Functional Antigen)
Clone: 23C6
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
Positive Control:

Tonsil

Cross Reactivity:

Human

Applications: Acetone, FACS, Frozen, Immunoprecipitation, Neutralising
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: P3X63Ag8.653
Relevance: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
References:

Horton MA et al. 1985. Cancer Res. 45(11 Pt2):5663-9. PMID: 4053038 Read more
Marshall JF et al. 1995. J. Cell. Sci. 108(Pt3):1227-38. PMID: 7542669 Read more

Notes:

125/124 kDa (reduced), 150kDa (non-reduced)