| Antigen: | Integrin alpha v/beta 6 |
| Clone: | avß6 53a.2 |
| Subclass | IgG2a |
| Species Raised In: | Rat |
| Immunogen: | Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera. |
| Epitope: | Extracelllular region of the heterodimer. |
| Positive Control: | BT20 breast carcinoma, original immunogen. |
| Applications: | FACS, Immunofluorescence, Neutralising |
| Growth Conditions: | RPMI 1640 + 3% FCS |
| Relevance: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target. |
| References: | Marsh et al. 2008. Cancer Research. 68:3295-303. PMID: 18451156 Read more |
| Notes: | Recommended Concentration: 10ug/ml |
© Cancer Research Technology 2012