| Antigen: | p75 Neurotrophin Receptor (Low-Affinity Nerve Growth Factor Receptor; LNGFR) |
| Clone: | p75 NTR(IC) |
| Species Raised In: | Rabbit |
| Immunogen: | Fragment corresponding to the intracellular domain of rat p75 NTR (residues 274-425) |
| Positive Control: | Rat and mouse lysates. |
| Cross Reactivity: | Murine, Rodent |
| Applications: | Western |
| Relevance: | The p75 neurotrophin receptor (p75NTR) is a major player in the regulation of neuronal cell death and survival. This receptor binds all four neurotrophins with approximately equal affinity in the nanomolar range, as well as the pro-neurotrophins. The binding of mature neurotrophins to p75NTR causes a variety of physiological responses, including neuronal survival and differentiation. In contrast, the interaction of p75NTR with pro-neurotrophins induces apoptosis in sympathetic neurons. We have two polyclonals available; one targets the intracellular portion of rat p75 and the other that targets the extracellular portion. |
| References: | Katrin Deinhardt et al. 2006. Neuron. Volume 52(2): 293-305. PMID: 17046692Read more |
| Notes: | Recommended dilution for WB: 1:500. |
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