| Antigen: | Nav 1.5 (Voltage-gated Sodium Channel Nav1.5) |
| Clone: | 4G8:1G7 |
| Subclass | IgM |
| Species Raised In: | CD-1 mouse |
| Immunogen: | Peptide (14mer) from an extracellular domain of Nav1.5 |
| Epitope: | Extracellular domain |
| Positive Control: | Cell lines over expressing Nav1.5, e.g., Nav 1.5-HEK293 Recombinant cell line from Upstate. |
| Cross Reactivity: | Human |
| Applications: | Immunofluorescence, Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2/0Ag.14 |
| Synonyms: | CDCD2 antibody, Voltage-gated Sodium Channel Nav1.5 antibody |
| Relevance: | Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5. |
| Notes: | 4G8:1G7 is recommended for Western blotting and Immunocytochemistry using 2ug/ml and 10ug/ml, respectively. |
© Cancer Research Technology 2012