| Antigen: | Siglec 5 |
| Clone: | 1A5 |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | Siglec-5-Fc protein, containing entire extracellular region of siglec-5 fused with the Fc region of human IgG1 |
| Positive Control: | Siglec 5 transfected CHO cells. Apart from Siglec-14 (Angata T et al. 2006 FASEB J. 20:1964-73. PMID: 17012248), non-cros |
| Cross Reactivity: | Siglec-14 |
| Applications: | Acetone, ELISA, FACS, Frozen, Immunofluorescence, Immunoprecipitation, Neutralising, Western |
| Growth Conditions: | DMEM + 10% FetalClone I + 1% penicillin/streptomycin |
| Fusion Partner: | Sp2 |
| Relevance: | The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Siglec-5 (CD170) is a member of the recently-described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system. Similar to other CD33- related siglecs, Siglec-5 contains two tyrosine based motifs in its cytoplasmic tails implicated in signalling functions. |
| References: | Cornish AL, et al. 1998 Blood 92:2123-32. PMID: 9731071 Read more |
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