Anti TAL-1 Clone 2TL242 Profile

Antigen: TAL-1 (SCL; TCL5)
Clone: 2TL242
Subclass IgG1 kappa
Species Raised In:

Mouse

Immunogen: Recombinant TAL-1 protein
Cross Reactivity:

Human

Applications: Frozen, Immunoprecipitation, Paraffin embedded
Growth Conditions:

RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT

Fusion Partner: NS1
Synonyms: T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, Class A basic helix-loop-helix protein 17, bHLHa17, BHLHA17
Relevance: TAL-1 is a member of the helix-loop-helix family of transcription factors. Overexpression of the TAL-1 gene is the most common molecular abnormality found in human T cell leukaemia.
References:

Bernard M et al. 1995. Blood 85:3356-7. PMID: 7756670 Read more
Pulford K et al. 1995. Blood 85:675-84. PMID: 7833471 Read more
Chetty R et al. 1996. J Pathol 178:311-5. PMID: 8778337 Read more
Chetty R et al. 1997. J Pathol 181:311-5. PMID: 9155718 Read more

Notes:

Please note this cell line has not been weaned out of HAT.  Ultroser G can be used at 1% if the cells are not growing well.