Anti TCP-1 Clone 22b, PK/4/22b/3i/5c Profile

Antigen: T-complex polypeptide-1 (TCP-1; CCTalpha)
Clone: 22b, PK/4/22b/3i/5c
Subclass IgG2a rat
Species Raised In:

Rat

Immunogen: C-terminal half of the full length murine TCP protein
Epitope:

544 LDD-COOH

Cross Reactivity:

Chicken, Rat, Hamster, Mouse, Dog

Applications: Immunoprecipitation, Western
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: Y3 Ag 1.2.3
Synonyms: CCT1, CCT alpha, p63, Tailless Complex Polypeptide, Tp63, TRic
Relevance: TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin.
References:

Harrison-Lavoie et al. 1993. EMBO J . 12:2847-53. PMID: 8335000 Read more
Willison K et al. 1989. Cell. 57:621-32. PMID: 2655925 Read more
McDowall A et al. 2003. J. Clin. Invest. 111(1):51-60. PMID: 12511588 Read more
Notes:

22b does not recognise primate, yeast or xenopus TCP-1 22b is monospecific for TCP-1, not reacting with similar proteins.