| Antigen: | Trefoil factor 1 (TFF1), also known as pS2 |
| Clone: | GE2 |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | A synthetic peptide of 28 amino acid residues from the C-terminus of human pS2 protein |
| Epitope: | Residues 57-84 (KGCCFDDTVRGVPWCF-YPNTIDVPPEEE) |
| Positive Control: | Normal stomach or breast carcinoma |
| Cross Reactivity: | Human |
| Applications: | Paraffin embedded |
| Relevance: | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
| References: | Williams R, et al. 1996. Hum Pathol.(12):1259-66.PMID: 8958295Read more |
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