| Antigen: | XPF |
| Clone: | XPF 3F2/3 |
| Subclass | IgG1 |
| Species Raised In: | Balb/c |
| Immunogen: | A recombinant His-tagged fragment of human XPF protein produced in E. coli |
| Epitope: | Residues 629-905 |
| Applications: | ELISA, Immunofluorescence, Western |
| Growth Conditions: | DMEM + 5% FCS |
| Fusion Partner: | Sp2/0Ag.14 |
| Relevance: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). |
| References: | Bhagwat et al. 2009. Cancer Research. 69(17):6831-8. PMID: 19723666Read more |
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