Anti XPG Clone 8H7/XPG Profile

Antigen: XPG
Clone: 8H7/XPG
Subclass IgG2a
Species Raised In:

Balb/c

Immunogen: Recombinant human XPG protein produced in baculovirus
Positive Control:

LnCap cells

Cross Reactivity:

Human

Applications: Immunoprecipitation, Western
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: Sp2
Relevance: XPG is a DNA endonuclease that is essential for the dual incision step of nucleotide excision repair (cleaves 3' of the DNA lesion). XPG might be involved in the DNA replication and repair deficiency syndromes Cockayne Syndrome and Xeroderma pigmentosa.
References:

Evans E et al. 1997. EMBO J. 16:625-38. PMID: 9034344 Read more
Araujo SJ et al. 2001. Mol. Cell. Biol. 21(7):2281-91. PMID: 11259578 Read more

Notes:

8H7/XPG stains XPG in the nuclei of human cells.