Anti XRCC2 Clone XRCC2 7B7/3 Profile

Antigen: X-Ray Repair Cross Complementing 2 (XRCC2)
Clone: XRCC2 7B7/3
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: His-tagged human XRCC2
Positive Control:

HeLa nuclear extracts.

Cross Reactivity:

Human

Applications: Western
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: Sp2/0Ag.14
Relevance: X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway.
References:

Masson JY et al. 2001. Genes Dev. 15:3296-307. PMID: 11751635Read moreCartwright R et al. 1998. Nucleic Acids Res. 26(13):3084-9. PMID: 9628903Read more

Notes:

XRCC2 7B7/3 does not recognise other paralogs.